By Vladimir Uversky,Yuri Lyubchenko
Bio-Nanoimaging: Protein Misfolding & Aggregation offers a distinct advent to either novel and tested nanoimaging suggestions for visualisation and characterization of misfolded and aggregated protein species. The booklet is split into 3 sections overlaying: - Nanotechnology and nanoimaging know-how, together with cryoelectron microscopy of beta(2)-microglobulin, learning amyloidogensis by means of agonize; and scanning tunneling microscopy of protein deposits - Polymorphisms of protein misfolded and aggregated species, together with fibrillar polymorphism, amyloid-like protofibrils, and insulin oligomers - Polymorphisms of misfolding and aggregation techniques, together with a number of pathways of lysozyme aggregation, misfolded intermediate of a PDZ area, and micelle formation by way of human islet amyloid polypeptide
Protein misfolding and aggregation is a fast-growing frontier in molecular drugs and protein chemistry. similar issues contain cataracts, arthritis, cystic fibrosis, late-onset diabetes mellitus, and various neurodegenerative ailments like Alzheimer's and Parkinson's. Nanoimaging know-how has proved the most important in realizing protein-misfolding pathologies and in power drug layout geared toward the inhibition or reversal of protein aggregation. utilizing those applied sciences, researchers can visual display unit the aggregation procedure, visualize protein aggregates and study their properties.
- Provides sensible examples of nanoimaging learn from major molecular biology, mobile biology, protein chemistry, biotechnology, genetics, and pharmaceutical labs
- Includes over two hundred colour pictures to demonstrate the facility of assorted nanoimaging applied sciences
- Focuses on nanoimaging suggestions utilized to protein misfolding and aggregation in molecular medicine
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Bio-nanoimaging: Protein Misfolding and Aggregation by Vladimir Uversky,Yuri Lyubchenko
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